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Researchers at Oregon Health Sciences University studied a strain of mice that were prone to spontaneous development of joint lesions similar to those in rheumatoid arthritis. They found that animals fed a diet that included a 3% solution of MSM, in drinking water from the age of two months until the age of five months, suffered no degeneration of articular cartilage. In the control group of mice receiving only tap water, 50% of the animals were found to have focal degeneration of articular cartilage.

Finally, recent human research at the UCLA School of Medicine found an 82% reduction in pain after six weeks of oral MSM use in a double blind study on degenerative arthritis. The study spanned four months and involved sixteen patients: ten patients on MSM and six on placebo. After only six weeks, those patients using the MSM experienced better than 80% control of their pain, while those on the placebo experienced on average an 18% improvement at six weeks.

MSM (methyl-sulfonyl-methane),also known as dimethyl sulfone, is a naturally occurring sulfur compound, found in human diets and those of virtually all other vertebrates. In its purified form, it is an odorless, slightly bitter tasting, water soluble, white, crystalline powder containing 34% elemental sulfur. Its chemical formula is (CH3)2SO2.

Some atmospheric chemists have suggested that MSM and its related compounds, DMSO (dimethylsulfoxide), and DMS (dimethylsulfide) provide the source for 85% of sulfur compounds in all living organisms.

These naturally occurring compounds begin in the ocean where phytoplankton convert inorganic sulfur present in the sea water to terniary dimethyl sulfonium salts. These salts are later broken down, by enzymatic action, into the volatile compound called dimethylsulfide (DMS), which escapes the ocean as a gas, rises into the upper atmosphere to be oxidized there in the presence of ozone and ultraviolet light to its chemical cousins, DMSO and MSM. Unlike DMS, both DMSO and MSM are water soluble and are returned to the earth in rain. Plants rapidly absorb the two compounds, concentrating them up to a hundred-fold.

Animals eat the plants and the distribution of these sulfur compounds is then complete. MSM has been found in the blood and adrenal glands of cows. Cows' milk contains between two and six parts per million MSM.

MSM occurs naturally in the human body as a result of the food we eat. It is a normal component of fresh fruits, vegetables, seafood and meat. It has also been found in tea, coffee and chocolate. It has been detected in normal human urine. The amount of MSM present in the circulatory system of an adult human male is about 0.2 parts per million. Normal adult humans excrete from four to eleven milligrams of MSM per day in their urine. In vertebrates, the concentration of MSM decreases with age.

Some research suggests that there is a minimum concentration of MSM that must be maintained in the body to preserve normal function and structure.

Experiments using MSM that contains radiolabled sulfur (35S) have shown that after ingestion, MSM gives up its sulfur to the essential amino acids methionine, cysteine and other serum proteins, eventually finding its way into the collagen of skin, joints and blood vessels. It is also incorporated into the keratin of hair and nails.

MSM is rated as one of the least toxic substances in biology. It is so inert and nontoxic that aqueous solutions can even be used as a blood diluent. In mice, no clinical changes were observed at oral doses of 2000 mg per kilogram of body weight. The lethal dose (LD50) of MSM for mice is over 20 grams per kilogram of body weight. Hundreds of patients have been treated at the Oregon Health Sciences University with oral MSM at levels above two grams daily for many years without serious toxicity.

These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.