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The mitochondria are tiny energy (ATP) producing powerhouses within our cells. Damage to mitochondrial DNA has been shown to be a marker for cancer and is considered a cause of aging. Antioxidants help protect mitochondrial DNA from free radical damage which they are very susceptible to. The following antioxidants are recommended for that purpose. These antioxidants work together and recycle each other (i.e. alpha lipoic acid regenerates and recycles “used” vitamin E.)

Alpha Lipoic Acid Slow Release
NAC
NADH
Unique E
PCO phytosome
Cyto-Redoxin

Oxygen is essential to life. It must be present in order for our cells to convert matter to energy. Metabolism involves the chemical changes that take place in our bodies to provide energy for vital processes and activities. The continuous and efficient production of energy is vital to our ability to function at peak levels in everything we do. Among the by-products of metabolism are free radicals.

A free radical is any substance with one or more unpaired electrons. They are the natural result of the normal metabolic process. They can also be the result of various lifestyle and environmental influences such as smoking, drinking alcohol, excessive exercise, pollution and over exposure to the sun. Free radicals are very reactive substances which roam throughout the body in search of their "missing electron". They can deform and corrode any partner they touch. When uncontrolled free radical reactions occur, they can damage vital biological molecules, cells, tissues and organs.

Today, the scientific community is devoting more time and research toward understanding free radicals. The reason for this research is the increasing realization that free radicals can have a potentially harmful effect on the cells in our bodies and that this oxidative stress may lead to more serious conditions. Researchers have found that antioxidant nutrients, which can neutralize, balance and sponge up free radicals-may be effective in combating free radical damage. Antioxidants, whether produced in the body or obtained through diet or supplementation, are substances which function to destroy free radicals by coupling with the unpaired electrons. When antioxidants do this, they themselves become free radicals.

The benefit obtained, however, is that the free radical antioxidant form is relatively unreactive and the antioxidant form can be regenerated by interacting with other antioxidant substances.

In 1991, researchers showed for the first time the synergistic action of the antioxidants vitamin E, vitamin C, Alpha Lipoic Acid and glutathione. This so called "antioxidant network" ensures comprehensive protection from free radicals. When research suggested that this "antioxidant network" plays an important role in the life process, the first congress on the significance of antioxidants in preventative medicine was held in Saas Fee, Switzerland in 1992. This congress led to the Declaration of Saas Fee which emphasized the role of natural antioxidants such as vitamin E, vitamin C, Alpha Lipoic Acid and carotenoids in disease prevention. The Declaration of Saas-Fee was signed by a large number of international experts and now has become the basis for worldwide initiatives of prevention.

DNA Damage A Culprit In Aging

NEW YORK, Oct 21 (Reuters Health) -- Mutations in the DNA found in mitochondria -- the tiny "powerhouses" that generate energy in cells -- accumulate over time and may contribute to the aging process, report researchers.

Comparing mitochondrial DNA from healthy young individuals to that of healthy older people, the investigators found that key mutations are more common with age. Scientists led by Dr. Yuichi Michikawa from the California Institute of Technology in Pasadena report the finding in the October 22nd issue of the journal Science.

The researchers found it "most striking" that one specific mutation occurred in 8 of 14 (or 57%) of individuals over the age of 65, but in none of the mitochondrial DNA from 13 younger individuals.

Results of a separate analysis of mitochondrial DNA from two sets of stored cells taken 9 to 19 years apart from nine individuals supports the role of age in the accumulation of mitochondrial DNA damage. In at least 3 of the 9 individuals, mitochondrial DNA mutations were evident in the cells taken later in life, but not cells from the same person when they were young.

According to Michikawa and colleagues, these mutations are not inherited but may be caused by free-radicals, unstable compounds formed during normal cell processes. Alternatively, the mutations may be due to cell enzymes that build DNA, or by problems with DNA repair mechanisms.

In an accompanying editorial, Elizabeth Pennisi says the findings provide "the first hard evidence that mitochondria do deteriorate as people age." Just how this deterioration affects the functioning or survival of cells remains to be determined, she adds.
SOURCE: Science 1999;286:664, 774-779.

Chayavanprash.

It is an Ayurvedic jelly. It contains 49 herbs plus the amla fruit (Indian gooseberry, Emblican officinalis). The amla is the main ingredient. Amla contains 3000 mg of vit c plus bioflavanoids, anti-oxidants, B complex, and carotenoids. Amla is the highest natural known source of vitamin C. Having 20 times the vitamin C content of an orange, Amla is also uniquely heat stable. Even when subjected to prolonged high heat, as in the making of the Ayurvedic tonic formula called Chyavanprash, Amla, as the primary herb comprising 50% of the formula, hardly loses any of the vitamin C that is present when it is freshly harvested off the tree. The same is true of Amla that has been dried and kept for up to a year. This age and heat stable form of vitamin C in Amla is due to the presence of certain tannins that bind and inhibit its dissipation. It boost digestion , increases muscle mass, lowers blood pressure and blood cholesterol, and enhances healing of tissue.

These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.